B.J. Upton hit two home runs and drove in three runs, Ryan Roberts also homered, and the Tampa Bay Rays defeated the White Sox 6-2 to all but eliminate the Sox from the American League Central title.
The Tigers' 2-1 win at Minnesota gave them a three-game lead over the Sox with three games to play, clinching a tie for Detroit. The Sox finish the season with three games in Cleveland while the Tigers play a three-game series in Kansas City.
Sox starter Jose Quintana (6-6) allowed four runs on six hits over four-plus inings.
Alex Rios drove in a run with a single in the fourth and Dayan Viciedo had a sacrifice fly in the sixth for the Sox (83-76), who lost for the 10th time in their last 12 games.
The paid attendance at U.S. Cellular Field was 26,831, brining the season paid attendance to 1,965,955 -- the first time since 2004 the Sox drew less than 2 million fans.