BOSTON -- Kevin Youkilis hit a three-run homer, and Philip Humber gave up two runs over six innings in the White Sox' 7-5 victory against the Red Sox on Tuesday night.

Youkilis, returning to Boston for the White Sox' four-game series after his trade to Chicago on June 24, also walked and scored the Sox' first run.

Youkilis unloaded against Red Sox left-hander Jon Lester in the fourth inning with Dayan Viciedo and Gordon Beckham on second and third. It looked as though Lester was issuing a semi-intentional walk running the count to 3-0 with left-handed hitting Adam Dunn on deck, but he took it to 3-2 before Youkilis hit his fourth homer since the trade.

Humber (4-4) made his 13th start but his first since June 16, returning from a sting on the disabled list with a tender elbow. With John Danks on the DL and Gavin Floyd going there Tuesday with elbow tendinitis, Humber's encouraging return served as a shot in the arm for a rotation that welcomes yet another rookie (left-hander Pedro Hernandez) for a spot start Wednesday night.

After giving up two runs on three singles to Jacoby Ellsbury, Carl Crawford and Adrian Gonzalez in the first, Humber settled into a good rhythm. He finished with five scoreless innings, allowing three hits in that span. He walked none and struck out three in a 104-pitch effort.

After White Sox rookie right-hander Brian Omogrosso pitched a perfect seventh, left-hander Matt Thornton gave up three runs in the eighth, two on Kelly Shoppach's pinch homer.

Addison Reed pitched a perfect ninth for his 15th save in 17 opportunities. Alex Rios made a nice running catch in right center on Jacoby Ellsbury's liner to end the game.