BOSTON -- Adrian Gonzalez hit a three-run, tiebreaking homer in the eighth inning against rookie left-hander Leyson Septimo, leading the Red Sox to a 5-1 victory against the White Sox on Monday night.

Dylan Axelrod pitched 6 2/3 innings of one-run ball for the White Sox, striking out a career-high eight and walking none. Septimo walked Carl Crawford and David Ortiz to open the eighth before Gonzalez hit the home run.

Kevin Youkilis, playing his first game as a visitor at Fenway Park, had two doubles and a single and scored the White Sox only run.

Youkilis alertly manufactured the Sox' run in the first by going from first to third on Adam Dunn's grounder to the right side. Will Middlebrooks, playing in the shortstop area on the Dunn shift, lost a foot race to third with Youkilis, who came all the way around and scored on first baseman Gonzalez's errant throw across the infield.