DETROIT -- Miguel Cabrera hit two of the Tigers' four homers against White Sox starter Philip Humber, and Detroit held on for a 6-4 win to complete a series sweep at Comerica Park on Sunday afternoon.

Alex Rios and Kevin Youkilis homered for the Sox, who lost their fifth game in a row and finished with a 3-7 record on a road trip through Kansas City, Boston and Detroit. The Tigers, who lead the Sox by one and a half games in the American League Central, have won 13 of their last 15.

Humber (4-5) allowed six runs on seven hits in three innings.

Sox relief pitchers Hector Santiago (3 1/3 innings), Nate Jones (2/3 of an inning) and Donnie Veal (one inning) combined for five innings of hitless relief.