Brandon Morrow held the White Sox to a pair of singles by A.J. Pierzynski, and Jose Bautista hit a 423-foot home run against rookie lefthander Jose Quintana as the Blue Jays defeated the White Sox 4-0 before 25,672 fans on Wednesday night.
The Sox, who were out-hit 13-2 by the Jays (30-26) lost to Toronto for the second straight time in their three-game series at U.S. Cellular Field, which wraps up Thursday night. The Sox (31-25) have dropped three of their last four games after winning nine in a row.
Quintana (1-1, 2.05) was good once again filling in for injured starter John Danks. He gave up two runs on nine hits with one strikeout and one walk over six innings. Danks, the Sox' Opening Day starter, threw a successful bullpen session on Wednesday and is expected to make a minor-league rehab start soon before returning to the rotation.
Rajai Davis hit a two-run homer against lefthander Hector Santiago in the ninth inning to increase Toronto's lead to 4-0. It was the sixth homer allowed by Santiago in 21 1/3 innings.
The Sox were without Paul Konerko, the American League's leading hitter with a .366 average. Konerko missed his second straight game after having a small, floating chip flushed out from his left wrist. Konerko said he hopes to return Thursday.
Morrow (7-3) pitched a complete game.