Paul Konerko will miss his second consecutive game Wednesday night after having a chip flushed from his left wrist on Tuesday. Konerko indicated he might not play Thursday but expects to be back by Friday at the latest. The Sox open a three-game series against the Astros on Friday.

Tyler Flowers will start at first base Wednesday against the Blue Jays for the first time this season. Konerko, who leads the American League with a .366 batting average, was a late scratch Tuesday after having the procedure done.

"It popped in on the off day [Monday],'' said Konerko, who had a similar procedure done last season in early June. "Then the race was on. This thing has been in there since the 2008 season. It's just one of those thing where, sometimes it would pop in there in the morning and I would somehow manipulate it out of there by the time I needed it. That's kind of how it always was. The last two years were the only two times where it ever got in the way of actually playing. ''

The Sox host the Toronto Blue Jays at 7:10 p.m., with rookie left-hander Jose Quintana opposing Jays right-hander Brandon Morrow.

Konerko said he will have surgery after the season to take care of it once and for all.