Philip Humber was at a loss after failing to get a win despite being staked to a 4-1 lead on Thursday night.
"I just wasn't very good,'' Humber said after giving up five runs in 4 1/3 innings in the White Sox' 11-8 victory against the Minnesota Twins at U.S. Cellular Field. "I don't know, man. I didn't command anything from the start. It's hard to figure out what's going on."
The Sox hit five home runs, including a grand slam by Alejandro De Aza after De Aza had a homer taken away by video replay in his previous at-bat. A.J. Pierzynski, Paul Konerko, Alex Rios and Dayan Viciedo also homered.
"I'm glad the team picked me up,'' said Humber (5.80 ERA), who hasn't won since his perfect game in Seattle and hasn't won at home in 12 starts, dating to June 12 against Oakland. "Great job by the lineup and the bullpen. I'm very disappointed with my effort."
The Sox have won six of their last seven games and brace themselves for a three-game series with the first-place Cleveland Indians in the AL Central. The Indians are coming off a three-game sweep of the AL Central favorite Detroit Tigers.
Konerko hit his 10th homer of the season and has stayed on a tear despite missing two games after getting hit near the eye by a pitch from the Cubs' Jeff Samardzija on Friday. He is 19-for-34 (.559) with four homers and nine RBI in his current 10-game hitting streak. The homer was the 45th of his career against the Twins, an opponent high for him.
De Aza's slam, the first of his career, highlighted a six-run sixth.
"It's big,'' manager Robin Ventura said. "We have kind of had those innings where we've given up a crooked number, to be able to come back the way we did. De Aza's grand slam, that's a big one for us. We haven't really had that inning where we cash them all in. It's nice to do that, just kind of keep it going. Rios and Paulie had a night, too.''
"Once you see a teammate hit a home run, you want to hit a home run,'' said De Aza, who has four as the leadoff man.
The homers by Pierzynski, Konerko and Rios -- who homered for the second consecutive night -- came against right-hander Cole De Vries, who was making his major league debut.
Sox relievers Nate Jones, Jesse Crain and Matt Thornton were not scored on, although Jones gave up a two-run single to Brian Dozier that was charged to Humber. Will Ohman and Addison Reed each gave up a home run to Justin Morneau.