BALTIMORE -- After serving up the 100th career homer of Nick Markakis' career in the third inning, Mark Buehrle buckled down and led the White Sox to a 6-3 victory against the Baltimore Orioles on Thursday night.

The Sox took three of four from the O's and finished their road trip with a 6-1 record going into a nine-game homestand that begins on Friday night.

After Markakis' homer, Buehrle (10-5) allowed five hits. His key inning was the fifth, when he left runners on second and third by striking out Markakis.

Opening the game with five straight hits against Chris Tillman (3-5), including a two-run homer by Alexei Ramirez that was followed with consecutive doubles by Paul Konerko (2-for-4), Carlos Quentin (1-for-5) and A.J. Pierzynski (3-for-5), the Sox gave Buehrle a 4-0 lead before he threw his first pitch.

Buehrle pitched eight innings. He struck out six and walked none. Sergio Santos pitched a perfect ninth for his 25th save.