NEW YORK -- Long reliever Tony Pena left during the fifth inning of the White Sox 12-3 loss at Yankee Stadium on Thursday night with discomfort in his right elbow.

Trainer Herm Schneider visited Pena on the pitcher's mound, and Pena appeared to be favoring his right arm. The Sox were losing 8-0 at the time. Pena was replaced by Will Ohman.

Pena had relieved starter Edwin Jackson during the inning after Jackson gave up a home run, double, triple and single to the first four Yankees batters. Pena faced five batters without getting an out, walking two and giving up three hits including a double to the wall by Alex Rodriguez.

Ohman retired all three batters he faced to end the inning, striking out Brett Gardner and Curtis Granderson.

The Yankees built their lead to 12-3 on a two-run homer by former Sox Nick Swisher in the seventh inning.