I recently spent two nights each at two of Houston's hottest hotels: Hotel ZaZa (opened last year) and Hotel Icon (recently wrapped up a major renovation).
Both were luxurious but in very different ways. Hotel ZaZa is a hipster haven -- make that hipsters with day jobs that mean they can afford the mid- to high-$200 starting rate for standard rooms. (The "petite" room category starts just under $200 and the rooms are trendy and chic, just a bit on the smaller side.)
ZaZa used to be the historic neoclassical Warwick hotel until a massive renovation turned it into swanky 315-room bastion of coolness. Especially funky are the themed suites decked out in clever motifs like the space theme in the "Houston, We Have a Problem" room.