Oprah Winfrey holds recently adopted puppy "Sadie" while Ali Wentworth holds "Ivan" on the show earlier this month. "Ivan" was adopted by Winfrey after the airing and died over the weekend.
A second golden cocker spaniel pup recently adopted by Oprah Winfrey died over the weekend from the deadly parvovirus.
Winfrey adopted Ivan -- the brother of the Sadie, the first puppy she adopted this month -- shortly after showing off the litter on her show March 6.
Both dogs were adopted from the PAWS animal shelter in Chicago.
Parvovirus is a deadly disease which can cause a canine to suffer from diarrhea, vomiting and lethargy.
"I'm saddened by his passing though we only had him for a weekend," Winfrey said in a statement to the Sun-Times. "I remain hopeful that Sadie will pull through."
Dr. Jean Dodds, D.V.M., said the two puppies were brought to Arboretum View Animal Hospital in Downer's Grove on Thursday. Dodds said at the time, Ivan was critically ill, however Sadie wasn't showing signs of the virus.
"Sadie was healthy until Thursday night," Dodds said. "It's a dicey situation because puppies can get sick very quick."
"They treated Sadie, but she is now very ill," Dodds said. "She became ill as quickly as [Ivan] did."
A Winfrey spokesperson told the Sun-Times that Sadie continues to get stronger and that she's stable for the first time since being admitted on Thursday.
"[Sadie's] white blood cell count did not drop overnight and she's holding her own," a spokeswoman said.
PAWS animal shelter released a statement Tuesday, wishing the best for Sadie.
"Our thoughts and prayers are with Oprah Winfrey on the loss of Ivan, and we are hopeful that Sadie makes a full recovery," a PAWS spokeswoman said.
"At PAWS Chicago, all of our animals receive excellent medical care. We take stringent precautions to prevent life-threatening diseases, including parvovirus. Our medical protocols are best-in-class in the industry and the steps we take prior to adoption include administering all required vaccinations, diagnostic testing, multiple veterinary checks, and a 14-day isolation period for puppies. Of the 501 puppies that PAWS Chicago took in during 2008, 99.2% either did not contract parvovirus or were cured of the disease."
Dodds, who runs Hemopet, a California-based organization which provides plasma to treat the virus, said Parvo is more life-threatening for dogs then people think, and that puppies shouldn't be vaccinated too young or too often.
The other two puppies seen on Winfrey's show -- Gordie and Webster -- are doing well and were also treated for the virus, according to Dobbs.