Kelly Faris scored inside with 13 seconds to play and Stefanie Dolson hit two free throws with three seconds left as No. 2 Connecticut overcame a seven-point second-half deficit for a 78-76 victory before a near-sellout crowd at the Joyce Center.
Notre Dame (13-4, 2-1 in the Big East) took a 76-75 lead when Natalie Novosel scored on a scoop layup in traffic with 30 seconds left. But after a time out, Connecticut worked the ball inside to Farris for an easy hoop that gave the Huskies the lead. Skylar Diggins missed a jumper from the wing with four seconds left and Dolson, a 6-5 freshman, rebounded and hit two free throws.
Notre Dame had one last chance, but Diggins' three-pointer from the corner under pressure was too long.
All-American Maya Moore led Connecticut (14-1, 4-0) with 31 points on 11-of-21 shooting. Faris added 20, including 10-of-10 free throws.
Senior Devereaux Peters of Fenwick led a balanced attack for Notre Dame with 17 points and 11 rebounds. Diggins and Novosel each scored 16. Natalie Achonwa came off the bench to score nine points and grab eight rebounds.