Bears safety Chris Harris, who has missed the last two games, practiced in full on Wednesday.
But Harris suffered a setback to his left hamstring, according to a source, and he's expected to miss at least Sunday's game against the Carolina Panthers, although he's officially listed as questionable.
"Yeah, it's disappointing not being able to play," Harris said after practice Friday. "But we've got the guys who can go out there and get the job done, and they will get the job done on Sunday."
The back end has looked anything but sharp without him, as the Bears have fielded several different combinations in his absence.
Second-year safety Major Wright practiced in full Thursday, so he will likely start with Brandon Meriweather.
Chris Conte and veteran Craig Steltz have also received playing time.
An All-Pro last season, after collecting five interceptions, Harris has proven to be one of the team's most dependable veterans.
"He's a guy who helps us go," Bears linebacker Lance Briggs said of Harris. "He's a general back there, and I look at him in the same respect that I looked at Mike Brown when he was here. He's a playmaker. He's a guy that we need on the field."
But, that won't be on Sunday.