Lance Briggs left the locker room after Sunday's game wearing a walking boot on his left ankle, casting doubt about his availability for Sunday's game.
Briggs aggravated a high-ankle sprain he first suffered in the third preseason game while stuffing Panthers running back Jonathan Stewart late in the third quarter.
"Lance is a good player and has consistently made plays," safety Chris Harris said. "It would hurt but we have very capable guys behind him in Brian Iwuh and Nick Roach. They can play pretty good football too so if Lance has to miss time, I don't think it will be a huge letdown."
Smith also said that tackle Chris Williams and safety Major Wright were improving from hamstring injuries and could be available this week.