SAN FRANCISCO--NFL.com reports that the San Francisco 49ers will sit wide receiver Isaac Bruce tonight.
He was listed as questionable for the game with an ankle injury.
That means that rookie first-round draft pick Michael Crabtree will be paired with Josh Morgan as the top targets for quarterback Alex Smith. Brandon Jones will likely serve as the third wide receiver, but tight end Vernon Davis is the top target for Smith.
Inactives for the game will be released in about an hour.