The Bears seemed pretty sure Tuesday afternoon that defensive end Mark Anderson would be back from surgery on his right thumb in time for the Sept. 7 season opener at Indianapolis.
Manning has been sidelined since surgery July 14 to remove an infected bursa sac from his left knee, and there has been increasing speculation the Bears could face Jim Sorgi in the opener and not the man named MVP of their Super Bowl XLI meeting.
"I don't think we can guarantee that," Colts coach Tony Dungy said. "I don't know if any of those [injured players] will be out there on the 7th, but my guess is they will be."
Those other injured guys include safety Bob Sanders and defensive end Dwight Freeney, who practiced in full pads for the first time Tuesday.
Manning has started 160 consecutive regular-season games and the initial diagnosis when he had surgery was for a return in four to six weeks. The Colts have not changed their course.