The nine-time Pro Bowl left guard has been placed on season-ending injured reserve.
Brown has battled a shoulder injury all season, and the decision was finally made to place him on IR and turn the job over to Terrence Metcalf, who has been the heir apparent for some time.
Taking Brown's place on the 53-man roster is guard/center Anthony Oakley.
Oakley was on the 53 all last season but did not participate in a game. This opens up a spot on the practice squad.